Inferring PDZ Domain Multi-Mutant Binding Preferences from Single-Mutant Data
نویسندگان
چکیده
منابع مشابه
Inferring PDZ Domain Multi-Mutant Binding Preferences from Single-Mutant Data
Many important cellular protein interactions are mediated by peptide recognition domains. The ability to predict a domain's binding specificity directly from its primary sequence is essential to understanding the complexity of protein-protein interaction networks. One such recognition domain is the PDZ domain, functioning in scaffold proteins that facilitate formation of signaling networks. Pre...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0012787